il-12 th1

il-12 th1

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferon-gamma production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV

Interleukin 12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-presenting cells (APCs) which plays a key role in promoting type 1 T helper cell (Th1) responses. The powerful activity of IL-12 requires tight control, which is exerted at various levels.

It promotes Th1 responses and is a powerful inducer of interferon gamma (IFN-γ). IL-12 is a heterodimeric 70 kDa cytokine composed of two subunits, p35 and p40. Recombinant human IL-12 is produced in Chinese hamster ovary (CHO) cells transfected with a

How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-γ (IFN-γ) alleles and by

As a central mediator of TH1 immune responses, interleukin 12 (IL-12) directly induces IFNγ release from activated NK, NKT and T cells, and is known to play a key role in driving anti-tumor responses. However systemic recombinant IL-12 was poorly tolerated in

CNBP controls IL-12 gene transcription and Th1 immunity Yongzhi Chen 1, Shruti Sharma 1,2, P atricia A. Assis 1, Zhaozhao Jiang 1, Roland Elling 1, Andrew J. Olive 3 , Saiyu Hang 4, Jennifer

IL-12 induces interferon-γ (IFN-γ) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naı ve CD4 + T cells into T helper 1 (Th1) cells that produce IFN-γ and aid in cell-mediated immunity.

BLAB/c 小鼠对利什曼原虫 通常是易感的,IL-12 体内能诱导 Th1 反应使小鼠抵抗感染。Th2 与抗蠕虫感染关系密切。 Th2 通过产生 IL-4 和 IL-5 诱导体液免疫应答,产生多种高水平的抗体,并引起嗜酸性粒细 胞和肥大细胞的聚集和活化,从而抑制寄生虫的感染。

Th1细胞主要分泌IL-2、IL-12、IFN-γ和TNF-β/等, 介导与细胞毒和局部炎症有关的免疫应答,参与细胞免疫及迟发型超敏性炎症的形成,故亦称为炎症性T细胞,可被视为相当于TDTH细胞。Th1细胞在抗胞内病原体(病毒、细菌及寄生虫等)感染中发挥重要作用。

狀態: 發問中


IL-12 R beta 2 dimerizes with IL-12 R beta 1 to form a functional IL-12 receptor complex. This renders the cells responsive to IL-12, which is critical for Th1 differentiation. IL-12 signaling stimulates STAT4-dependent expression of IFN-gamma and IL-18 R beta.

3.病毒性的感染,會誘導樹突細胞分泌IL-12(IL-12由p40和p35組合而成) ->IL-12會作用於NK cell;NK cell再分泌IFN-γ ->整個環境告訴免疫系統要走向TH1(因為TH1所幫助的細胞性免疫,專殺被微生物感染到胞內的細胞,ex:病毒性的、intracellular bacteria的

IL-12 In general, IL-12 is the most important cytokine that initiates Thl cell differentiation. IL-12 promotes Th1 differentiation by activating STAT4 and subsequently upregulating the expression of IFN-γ [7]. IL-12Rβ2 is only expressed in Th1 cells, but IL-4 can inhibit IL-12Rβ2 expression, resulting in T cells not responding to IL-12, prompting T cells to differentiate into Th2 [8].

IL‐12‐polarized, IFN‐γ‐producing Th1 cells were once thought to be critical autoimmune effector cells in EAE as well as MS 10, 11. However, their relevance was challenged by the observations that mice deficient in IL‐12, the IL‐12 receptor, or IFN‐γ are highly12-14

Th1-type cytokines tend to produce the proinflammatory responses responsible for killing intracellular parasites and for perpetuating autoimmune responses. Interferon gamma is the main Th1 cytokine. Excessive proinflammatory responses can lead to uncontrolled tissue damage, so there needs to be a mechanism to counteract this.

Tg4 splenocytes, were differentiated into Th1 cells in the presence of IL-12 and anti-IL-4 and were subsequently stimulated a further two times with antigen-presenting cells (APCs) and MBP peptide.

インターロイキン-12(英: Interleukin-12, IL-12)は、インターロイキングループのサイトカインの一つである。 IL-12p70は二つのサブユニット、IL-12p35とIL-12p40からなるヘテロ二量体で、主に食細胞と樹状細胞で産生される[1]。IL-12は1989年に初めて発見されたNK細胞

(A) The biological activity of Human Recombinant IL-12 was tested by its ability to produce IFN-gamma in NK cells co-stimulated with IL18. The EC50 is defined as the effective concentration of the growth factor at which IFN-gamma production is at 50% of maximum.

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IL-12, but Not IFN- , Promotes STAT4 Activation and Th1 Development in Murine CD4 T Cells Expressing a Chimeric Murine/Human Stat2 Gene1 Meredith E. Persky,* Kenneth M. Murphy,†‡ and J. David Farrar2* Humans and mice have evolved distinct pathways for

The interleukin (IL)-12 family, which is composed of heterodimeric cytokines including IL-12, IL-23, and IL-27, is produced by antigen-presenting cells such as macrophages and dendritic cells and plays critical roles in the regulation of helper T (Th) cell differentiation.

CT induces Th1 responses independently of IL-12 Given that CT has been shown to inhibit IL-12 production by antigen-presenting cells, 23, 24 we asked whether the observed IFN-γ response in OT-II

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Distribution of the human Th1 regulatory cytokine receptors for IL-12 and IL-18 on T-cells from adult blood, cord blood and tonsil tissue in health and in Th1/Th2-associated diseases M. Bofill Institució Catalana de Recerca i Estudis Avançats, Irsicaixa, Hospital

We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising.Typically IL-12 plus anti-IL-4 are needed in Th1

Enhanced expression of IL-12 associated with Th1 cytokine profiles in active pulmonary sarcoidosis David Moller, Jeffrey D. Forman, Mark Chang Hwa Liu, Paul W. Noble , Brian M. Greenlee, Prachi Vyas, David A. Holden, Joseph M. Forrester, Angeline Lazarus

La risposta TH1 è orientata in senso citotossico nei confronti di virus e batteri. È sostenuta dall’IFN-γ (che attiva la produzione di radicali liberi, NO soprattutto, da parte dei macrofagi e inibisce la risposta TH2) e dall’IL-12 (che stimola le cellule NK a produrre IFN

In this study we examined mechanisms that regulate T-helper lymphocyte 1 (Th1) commitment in Helicobacter pylori -infected human gastric mucosa. The levels of gamma interferon (IFN-γ), interleukin-4 (IL-4), and IL-12 in total extracts of gastric biopsies taken from

The interleukin (IL)-12/IL-23-mediated Th1/Th17 signaling pathway has been associated with the etiopathogenesis of primary biliary cirrhosis (PBC). To address the cytokine microenvironment specifically in the liver, we examined the localized expression of cytokine

IL 12 as INFgamma promote the Th1 activity, linked also to autoimmunity. In our research field, autism. increased levels of either IL 12 and INF gamma has been reported suggesting the stimulation

IL-12: Products IL-12 (Interleukin-12) is a heterodimeric cytokine that consists of a p35 and a p40 subunit. p40 is also a subunit of the cytokine IL-23. IL-12 enhances the cytotoxic activity and induces IFN-gamma production in NK cells, T cells, and dendritic epidermal T cells, and it promotes a Th1 biased immune response.

Th1细胞: Th0细胞在IL-12等细胞因子作用下分化而成,Th1细胞为CD4阳性细胞,主要分泌IL-2(白细胞介素2)、IFN-γ(γ干扰素)、TNF(β肿瘤坏死因子)等,功能为参与调节细胞免疫,辅助细胞毒性T细胞分化,介导细胞免疫应答,参与迟发型超敏反应等。

狀態: 發問中

Indeed, IL-12 responsiveness, as measured by the ability to phosphorylate STAT4 after in vitro IL-12 treatment, emerged in only a small fraction of Treg cells between days 3–5 postinfection, after production of IL-12 had ceased (Figure 6B, right).

IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against

The instruction model holds that naive T cells are instructed to differentiate into either Th1 or Th2 cells by virtue of the cytokine environment that surrounds them. That is, if naive T cells find themselves in the presence of IL-12, they will differentiate into Th1 cells

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IFN-c and IL-12 synergize to induce Th1/Th17 cells Following restoration of responsiveness to IL-12 by prestimula-tion with IFN-g, expression of the Ifng gene could be induced by IL-12 stimulation (Fig. 4A). All of the cells uniformly had upregulated T-bet expression


CD4+ T cells producing interleukin-10 (IL-10) and interferon-γ (IFN-γ) are reported in chronic infections. However, the signals that direct the development of IL-10-producing T helper 1 (Th1) cells are undefined. We showed that development of IL-10-producing Th1 cells required high T cell receptor (TCR) ligation, sustained ERK1 and ERK2 MAP kinases phosphorylation, and IL-12-induced STAT4

To date, the precise mechanism by which sequential activation of Th2 and Th1 cells in AD is achieved is unknown. IL-12 induces the differentiation and maturation of human Th cells into Th1-type cells and recent circumstantial evidence suggests that in AD

The balance of IL‐4 and IL‐12 present du Early Th1 / Th2 cell polarization in the absence of IL‐4 and IL‐12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells – Noble – 2001 – European Journal of Immunology – Wiley Online Library

Producen interleucinas que incluyen IL-4, IL-5, IL-6, IL-10 e IL-13. Las células efectoras principales de las células auxiliares TH2 son las células B. La principal diferencia entre las células auxiliares TH1 y TH2 es el tipo de respuesta inmune que generan.. 1.

The polarising cytokine IL-12 is responsible for triggering TH1 immune responses, while the polarizing cytokines, including IL-4 and IL-2, trigger TH2 immune responses. Hence, this is another difference between TH1 and TH2 immune response. Type of Cytokines

Artículo Original Nmunomodulación de Uncaria tomentosa sobre células dendríticas, il-12 y perfil TH1/TH2/TH17 en cáncer de mama Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer César Núñez 1,2,a, Iván Lozada-Requena 1,2,b, Tíndara Ysmodes 1,c, Daniel Zegarra 1,d, Fatima Saldaña 1,d, José Aguilar 1,e

R Manetti, P Parronchi, M G Giudizi, M P Piccinni, E Maggi, G Trinchieri, S Romagnani; Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells..

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Novel IL-12 family members shed light on the orchestration of Th1 responses Frank Brombacher1, Robert A. Kastelein2 and Gottfried Alber3 1University of Cape Town, Division of Immunology, Groote Schuur Hospital, 7925 Cape Town, South Africa 2DNAX Research Institute, 901 California Avenue, Palo Alto, CA 94304, USA

p40は、活性化されたマクロファージ(Mφ)やB細胞が、産生する。IL-12は、T細胞により産生されない唯一のサイトカインである。 抗原提示細胞(樹状細胞、マクロファージ)が分泌するIL-12は、ナイーブヘルパーT細胞(Th0細胞)を、Th1細胞に分化させる。T細胞

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cytes Th1, exerce quant lui un effetà stimulant sur les prcurseurs pDC2é en les protgeant de lé apoptose’ induite par l’IL-4(figure 1). Dans le modèle actuel de la différen-ciation Th1/Th2, l’IL-12 est le princi-pal facteur de diffrenciation Th1,é tandis que lIL-4 est

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外科と代謝・栄養49 巻6 号 2015 年12 月 – 327 -はじめに Interleukin-18(IL-18)は,1995 年に兵庫医 科大学の岡村春樹教授が世界に先駆け発見したサ イトカインである 1).当時は,1986 年にMos- mann らが発表したTh1,Th2 理論が話題となっ

Th1とTh2 分化したTh細胞はそれぞれサイトカインを産生する。 Th1細胞(細胞性免疫に関与)が作るサイトカインはIL-2とIFN-γで、IL-2は自分自身を活性化し、IFN-γは自分自身の活性化と共に、先に述べたがマクロファージの活性化と抗ウィルス作用に関与する。

CONCLUSION:Our data emphasize the pathogenic relevance of IL-12/Th1 and IL-23/Th17 in the evolution of PBC.Of significance, however, the shift from a Th1 to a Th17 imbalance at advanced stages of the disease suggests the necessity to consider modulation of

Lin C‐W, Su I‐J, Chang J‐R, Chen Y‐Y, Lu J‐J, Dou H‐Y. Recombinant BCG coexpressing Ag85B, CFP10, and interleukin‐12 induces multifunctional Th1 and memory T cells in